ABSTRACT:
In this article, we will discuss about the molecular and genetic basis of allergic infections. Allergic reactions arise from the abnormal immune response to harmless substances called allergens. Basically, allergens are non-infectious substances that can cause allergic reactions due to multiple factors. We will discuss here about the epigenetic modifications that causes allergic reactions. We will also provide related references to understand the concept deeply.
INTRODUCTION OF MOLECULAR AND GENETIC BASIS OF ALLERGIC REACTIONS:
Allergic infections, such as asthma, hay fever, and food allergies, affect millions of people worldwide. These conditions arise from an abnormal immune response to harmless substances, known as allergens. While the exact causes of allergic infections are multifactorial, recent advancements in molecular and genetic research have shed light on the underlying mechanisms. This article aims to explore the molecular and genetic basis of allergic infections, providing a comprehensive understanding of these conditions.
MOLECULAR AND GENETIC BASIS OF ALLERGIC INFECTIONS:
1. MOLECULAR BASIS OF ALLERGIC INFECTIONS:
Allergic infections involve a complex interplay between the immune system, allergens, and various cells and molecules. The primary immune cells involved in allergic reactions are mast cells and basophils. These cells express high-affinity receptors for immunoglobulin E (IgE), which are responsible for recognizing and binding to allergens. Upon allergen exposure, IgE antibodies bind to mast cells and basophils, sensitizing them. Subsequent exposure to the same allergen triggers the release of inflammatory mediators, such as histamine, leukotrienes, and cytokines. These mediators cause the characteristic symptoms of allergic infections, including itching, swelling, and bronchoconstriction.
2. GENETIC BASIS OF ALLERGIC INFECTIONS:
Genetic factors play a significant role in determining an individual’s susceptibility to allergic infections. Numerous studies have identified specific genes and genetic variations associated with increased risk or protection against allergies. One of the most well-studied genes is the filaggrin gene (FLG), which encodes a protein crucial for maintaining the skin barrier. Mutations in the FLG gene have been linked to atopic dermatitis, a common allergic skin condition. Other genes involved in allergic infections include those encoding cytokines (e.g., IL-4, IL-13), chemokines (e.g., CCL5, CCL11), and toll-like receptors (e.g., TLR2, TLR4). These genetic variations influence immune responses, barrier function, and the production of inflammatory molecules, ultimately contributing to the development of allergic infections.
3. EPIGENETIC MODIFICATIONS:
In addition to genetic variations, epigenetic modifications also play a role in allergic infections. Epigenetics refers to changes in gene expression that do not involve alterations in the DNA sequence. DNA methylation, histone modifications, and microRNA regulation are examples of epigenetic mechanisms that can influence allergic responses. Studies have shown that DNA methylation patterns in specific genes, such as those involved in immune regulation, can influence the risk of developing allergies. Similarly, alterations in histone modifications can affect gene expression and immune responses. Understanding these epigenetic modifications provides insights into the molecular mechanisms underlying allergic infections.
CONCLUSION:
The molecular and genetic basis of allergic infections is a complex and multifaceted field of research. Advances in molecular biology and genetics have significantly contributed to our understanding of these conditions. By unraveling the intricate interactions between immune cells, allergens, and genetic factors, researchers can develop targeted therapies and interventions to alleviate the burden of allergic infections.
REFERENCES:
Galli SJ, Tsai M. IgE and mast cells in allergic disease. Nat Med. 2012;18(5):693-704. https://pubmed.ncbi.nlm.nih.gov/22561833/
Kabesch M. Gene by environment interactions and the development of asthma and allergy. Toxicol Lett. 2006;162(1):43-48. https://pubmed.ncbi.nlm.nih.gov/16439069/
Weidinger S, Novak N. Atopic dermatitis. Lancet. 2016;387(10023):1109-1122. https://pubmed.ncbi.nlm.nih.gov/26377142/
Martino D, Prescott S. Epigenetics and prenatal influences on asthma and allergic airways disease. Chest. 2011;139(3):640-647. https://pubmed.ncbi.nlm.nih.gov/21362650/
Zhang Y, et al. Epigenetics in allergic diseases and asthma: from mechanisms to therapies. Curr Opin Immunol. 2018;54:105-110. https://pubmed.ncbi.nlm.nih.gov/26418323/
